Klinik für Frauenheilkunde und Geburtshilfe - Lehrstuhl der Universität Regensburg


Wissenschaftliche Aufsätze


Fiedler M, Schulz D, Piendl G, Brockhoff G, Eichberger J, Menevse AN, Beckhove P, Hautmann M, Reichert TE, Ettl T, Bauer R: Buparlisib modulates PD-L1 expression in head and neck squamous cell carcinoma cell lines. Exp Cell Res, doi.org/10.1016/j.yexcr.2020.112259, Sept 2020 

Wege AK, Kirchhammer N, Kazandjian LV, Prassl S, Brandt M, Piendl G, Ortmann O, Fischer S, Brockhoff G: A novel rabbit derived anti-HER2 antibody with superior therapeutic effectiveness on HER2 positive breast cancer cells in-vitro and in humanized tumor mice (HTM). J Transl Med. 2020 Aug 15;18(1):316. 

Schulz D, Streller M, Piendl G, Brockhoff G, Reichert TE, Menevse AN, Beckhove P, Hautmann MG, Bauer RJ, Ettl T: Differential localization of PD-L1 and Akt-1 involvement in radioresistant and radiosensitive cell lines of head and neck squamous cell carcinoma. Carcinogenesis. 2020 Jul 14;41(7):984-992.


Bundscherer AC, Ullrich V, Malsy M, Gruber MA, Graf BM, Brockhoff G, Sinner B. Effects of Volatile Anesthetics on Proliferation and Viability of SW480 Colon Cancer Cells In Vitro. Anticancer Res. 2019 Nov;39(11):6049-6055. 

Brockhoff G. Target HER Four Cancer? A research perspective. Oncotarget. 2019 May 7;10(34):3147-3150. 

Schulz D, Stancev I, Sorrentino A, Menevse AN, Beckhove P, Brockhoff G, Hautmann MG, Reichert TE, Bauer RJ, Ettl T. Increased PD-L1 expression in radioresistant HNSCC cell lines after irradiation affects cell proliferation due to inactivation of GSK-3beta. Oncotarget. 2019 Jan 15;10(5):573-583.


Wege AK, Chittka D, Buchholz S, Klinkhammer-Schalke M, Diermeier-Daucher S, Zeman F, Ortmann O, Brockhoff G. HER4 expression in estrogen receptor-positive breast cancer is associated with decreased sensitivity to tamoxifen treatment and reduced overall survival of postmenopausal women. Breast Cancer Res. 2018 Nov20;20(1):139.

Wege AK, Chittka D, Buchholz S, Klinkhammer-Schalke M, Diermeier-Daucher S, Zeman F, Ortmann O, Brockhoff G. HER4 expression in estrogen receptor-positive breast cancer is associated with decreased sensitivity to tamoxifen treatment and reduced overall survival of postmenopausal women. Breast Cancer Res. 2018 Nov 20;20(1):139.

Brawanski K, Brockhoff G, Hau P, Vollmann-Zwerenz A, Freyschlag C, Lohmeier A, Riemenschneider MJ, Thomé C, Brawanski A, Proescholdt MA. Efficacy of D,L-methadone in the treatment of glioblastoma in vitro. CNS Oncol. 2018 Jul 1;7(3):CNS18.]

Rom-Jurek EN, Kirchhammer N, Ugocsai P, Ortmann O, Wege AK, Brockhoff G: Regulaton of PD-L1 expression in breast cancer cell lines in-vitro and in immunodecient NSG and humanized NSG mice. Int J Mol Sci, 2018 Feb 13;19(2). pii: E563. 

Hoffmann M, Pasch S, Schamberger T, Maneck M, Möhlendick B, Schumacher S, Brockhoff G, Knoefel WT, Izbicki J, Polzer B, Stöcklein NH, Klein CA: Diagnostic pathology of early systemic cancer: ERBB2 gene amplification in single disseminated cancer cells determines patient survival in operable esophageal cancer. Int J Cancer, 2018 Feb 15;142(4):833-843.

Baumann A, Buchberger AMS, Piontek G, Schüttler D, Rudelius M, Reiter R, Gebel L, Piendl G, Brockhoff G, Pickhard A: The Aurora-Kinase A Phe31-Ile Polymorphism as possible predictor of response to treatment in head and neck squamous cell carcinoma. Oncotarget. 2018 Jan 30;9(16):12769-12780. eCollection 2018 Feb 27.

Brockhoff G, Seitz S, Weber F, Zeman F, Klinkhammer-Schalke M, Ortmann O, Wege AK: The presence of PD-1 positive tumor infiltrating lymphocytes in triple 2 negative breast cancers is associated with a favorable outcome of disease. Oncotarget. 2017 Dec 27;9(5):6201-6212. eCollection 2018 Jan 19.


Lang S, Herrmann M, Pfeifer C, Brockhoff G, Zellner J, Nerlich M, Angele P, Prantl L, Gehmert S, Loibl M: Leukocyte-reduced platelet-rich plasma stimulates the in vitro proliferation of adipose-tissue derived mesenchymal stem cells depending on PDGF signaling. Clin Hemorheol Microcirc. 2017;67(2):183-196.

Reinders Y, Felthaus O, Brockhoff G, Pohl F, Ahrens N, Prantl L, Haubner F: Impact of platelet-rich plasma on viability and proliferation in wound healing processes after external radiation. Int J Mol Sci. 2017 Aug 22;18(8).

Hilber F, Loibl M, Lang S, Kerschbaum M, Brockhoff G, Angele P, Zellner J, Schmitz P, Nerlich M, Worlicek M: Leukocyte-reduced platelet-rich plasma increases proliferation of tenocytes treated with prednisolone: a cell cycle analysis. Arch Orthop Trauma Surg. 2017 Oct;137(10):1417-1422.

Holzschuh MA, Czyz Z, Hauke S, Inwald EC; Polzer BM, Brockhoff G: HER2 FISH results in breast cancers with increased CEN17 signals using alternative chromosome 17 probes - reclassifying cases in the equivocal category. Histopathology. 2017 Oct;71(4):610-625.

Inwald EC, Ortmann O, Koller M, Zeman F, Hofstädter F, Evert M, Brockhoff G, Klinkhammer-Schalke M: Screening-relevant age threshold of 70 years and older is a stronger determinant for the choice of adjuvant treatment in breast cancer patients than tumor biology. Breast Cancer Res Treat 2017 May;163(1):119-130.

Wege AK, Weber F, Nimmerjahn F, Kroemer A, Ortmann O, Brockhoff G: IL-15 enhances the anti-tumor activity of trastuzumab against breast cancer cells but causes fatal side effects in humanized tumor mice (HTM). Oncotarget. 2017 Jan 10;8(2):2731-2744. 


Hanke A, Prantl L, Wenzel C, Nerlich M, Brockhoff G, Loibl M, Gehmert S. Semi-automated extraction and characterization of Stromal Vascular Fraction using a new medical device. Clin Hemorheol Microcirc. 2016;64(3):403-412.

Loibl M, Lang s, Hanke AH, Herrmann M, Huber M, Brockhoff G, Klein S, Nerlich M, Angele P, Prantl L, Gehmert S: Leukocyte-reduced platelet-rich plasma alters protein expression of adipose-tissue derived mesenchymal stem cells. Plast Reconstr Surg. 2016 Aug;138(2):397-408.

Brockhoff G, Bock M, Zeman f, Hauke S: Bringing flexibility to HER2 FISH: The FlexISH assay brings flexibility to the cytogenetic HER2 testing. Histopathology. 2016 Oct;69(4):635-46.

Loibl M, Lang S, Brockhoff G, Gueorguiev B, Hilber F, Worlicek M, Baumann F, Grechenig S, Zellner J, Huber M, Valderrabano V, Angele P, Nerlich M, Prantl L, Gehmert S. The effect of leukocyte-reduced platelet-rich plasma on the proliferation of autologous adipose-tissue derived mesenchymal stem cells. Clin Hemorheol Microcirc. 2016;61(4):599-614.

Ach T, Schwarz-Furlan S, Ach S, Agaimy A, Gerken M, Rohrmeier C, Zenk J, Iro H, Brockhoff G, Ettl T: Genomic aberrations of MDM2, MDM4, FGFR1 and FGFR3 are associated with poor outcome in patients with salivary gland cancer. J Oral Pathol Med. 2016 Aug;45(7):500-9.


Ach T, Schwarz-Furlan S, Ach S, Agaimy A, Gerken M, Rohrmeier C, Zenk J, Iro H, Brockhoff G, Ettl T: Genomic aberrations of MDM2, MDM4, FGFR1 and FGFR3 are associated with poor outcome in patients with salivary gland cancer. J Oral Pathol Med. 2015 Dec 14. doi: 10.1111/jop.12394. [Epub ahead of print]

Inwald EC, Koller M, Klinkhammer-Schalke M, Zeman F, Hofstädter F, Gerstenhauer M, Brockhoff G, Ortmann O: 4-IHC classification of breast cancer subtypes in a large cohort of a clinical cancer registry: use in clinical routine for therapeutic decisions and its effect on survival. Breast Cancer Res Treat. 2015 Oct;153(3):647-58.

Döscher J, Piontek G, Wirth M, Bettstetter M, Schlegel J, Haller B, Brockhoff G, Reiter R, Pickhard A: Epstein-Barr Virus infection is strictly associated to Metastatic Spread of Sinonasal Squamous-Cell Carcinomas. Oral Oncol. 2015 Oct;51(10):929-34

Schuettler D, Piontek G, Wirth M, Haller B, Reiter R, Brockhoff G, Pickhard A: Selective inhibition of EGFR downstream signaling reverses irradiation enhanced migration of HNSCC cells. Am J Cancer Res 2015 Aug 15;5(9):2660-2672

Huber S, Wege AK, Bernhardt G, Buschauer A, Brockhoff G: Topotecan-induced ABCG2 expression in MCF-7 cells is associated with decreased CD24 and EpCAM expression and a loss of tumorigenicity. Cytometry A. 87A: 707-716, 2015


Loibl M, Lang S, Brockhoff G, Gueorguiev B, Hilber F, Worlicek M, Baumann F, Grechenig S, Zellner J, Huber M, Valderrabano V, Angele P, Nerlich M, Prantl L, Gehmert S. The effect of leukocyte-reduced platelet-rich plasma on the proliferation of autologous adipose-tissue derived mesenchymal stem cells. Clin Hemorheol Microcirc. 2014 Dec 23. [Epub ahead of print]

Schiefler C, Piontek G, Mißlbeck M, Rudelius M, Haug A, Reiter R, Brockhoff G, Pickhard A: Inhibition of SphK1 reduces radiation-induced migration and improves cetuximab treatment due to crosstalk between EGFR and SphK1. Oncotarget 2014 Sep 10. [Epub ahead of print]

Pickhard A, Huhn M, Siegel M, Reiter R, Baumann A, Rudelius M, Piontek G, Brockhoff G: Response of head and neck squamous carcinoma cells (HNSCC) to cetuximab treatment depends on the STK15/Aurora kinase A Phe31-Ile polymorphism. Oncotarget, 2014 Jul 30;5(14):5428-38.

Wege AK, Schmidt M, Ueberham E, Ponnath M, Ortmann O, Brockhoff G, Lehmann J: Co-transplantation of human hematopoietic stem cells and human breast cancer cells in NSG mice: a novel approach to generate tumor cell specific human antibodies. MAbs. 2014 Jul 1;6(4):968-77.

Ingargiola M, Runge R, Heldt JM, Freudenberg R, Steinbach J, Cordes N, Baumann M, Kotzerke J, Brockhoff G, Kunz-Schughart LA: Curative potential of a Cetuximab-based radioimmunotherapy (RIT) combined with external irradiation manifests in a 3-D cell assay. Int J Cancer. 2014 Aug 15;135(4):968-80.

Gehmert S, Wenzel C, Loibl M, Brockhoff G, Huber M, Krutsch W, Nerlich M, Gosau M, Klein S, Schreml S, Prantl L, Gehmert S. Adipose Tissue-Derived Stem Cell Secreted IGF-1 Protects Myoblasts from the Negative Effect of Myostatin. Biomed Res Int. 2014;2014:129048.

Pickhard A, Piontek G, Seidl C, Kopping S, Blechert B, Mißlbeck M, Brockhoff G, Bruchertseifer F, Morgensterne A, Essler M: 213Bi-anti-EGFR radioimmunoconjugates and X-ray irradiation trigger different cell death pathways in squamous cell carcinoma cells. Nucl Med Biol. 2014 Jan;41(1):68-76.


Machleidt A, Buchholz S, Diermeier-Daucher S, Ortmann O, Brockhoff G: The prognostic value of Her4 receptor isoform expression in triple negative and Her2 positive breast cancer patients. BMC Cancer. 2013 Sep 24;13(1):437.

Krüger JM, Thomas M, Korn R, Dietmann G, Rutz C, Brockhoff G, Specht K, Hasmann M, Feuerhake F: Detection of truncated HER2 forms in formalin-fixed, paraffin-embedded breast cancer tissue captures heterogeneity and is not affected by Her2-targeted therapy. Am J Pathol. 2013 Aug;183(2):336-43.

Ettl T, Gosau M, Brockhoff G, Schwarz-Furlan S, Agaimy A, Reichert TE, Rohrmeier C, Zenk J, Iro H: Predictors for cervical lymph node metastases in salivary gland cancer. Head Neck. 2013 Jun 18. doi: 10.1002/hed.23332.

Ach T, Zeitler K, Schwarz-Furlan S, Baader K, Agaimy A, Rohrmeier C, Zenk J, Gosau M, Reichert TE, Brockhoff G, Ettl T: Aberrations of MET are associated with copy number gain of EGFR and loss of PTEN and predict poor outcome in patients with salivary gland cancer. Virchows Arch. 2013 Jan;462(1):65-72.


Wege AK, Schardt K, Schaefer S, Kroemer A, Brockhoff G, Jung EM: High resolution Ultrasound including Elastography and Contrast-Enhanced Ultrasound (CEUS) for early detection and characterization of tumor lesions and pathological alterations in the liver of humanized tumor mice - a new imaging based approach to study tumor outgrowth in-vivo. Clin Hemorheol Micro. 2012 Jan 1;52(2):93-106.

Viale-Bouroncle S Gosau M, Küpper K, Möhl C, Brockhoff G, Reichert TE, Schmalz G, Ettl T, Morsczeck C: Rigid matrix supports osteogenic differentiation of stem cells from human exfoliated deciduous teeth (SHED). Differentiation. 2012 Nov 6;84(5):366-370.

Diermeier-Daucher S, Ortmann O, Buchholz, S, Brockhoff G: Trifunctional antibody Ertumaxomab: non-immunological effects on Her2 receptor activity and downstream signaling. MAbs. 2012 Sep-Oct;4(5):614-22.

Ettl T, Baader K, Stiegler C, Müller M, Agaimy A, Zenk J, Kühnel T, Gosau M, Zeitler K, Schwarz S, Brockhoff G: Loss of PTEN function is associated with EGFR and HER2 signalling in high-grade salivary gland cancer. Br J Cancer. 2012 Feb 14;106(4):719-26.

Ettl T, Stiegler C, Zeitler K, Zenk J, Hartmann A, Reichert TE, Kühnel T, Brockhoff G Schwarz S: EGFR, HER2, Survivin and loss of pSTAT3 characterize high-grade malignancy in salivary gland cancer with impact on prognosis and therapy. Hum Pathol. 2012 Jun;43(6):921-31.

Viale-Bouroncle S, Felthaus O, Schmalz G, Brockhoff G, Reichert T, Morsczeck C: The transcription factor DLX3 regulates the osteogenic differentiation of human dental follicle precursor cells. Stem Cells Dev. 2012 Jul 20;21(11):1936-47.


Lehner B, Sandner B, Marschallinger J, Lehner C, Furtner T, Couillard-Despres S, Rivera F, Brockhoff G, Bauer HC, Weidner N, Aigner L: The dark side of BrdU in neural stem cell biology: detrimental effects on cell cycle, differentiation and survival. Cell Tissue Res. 2011 Sep;345(3):313-28. doi: 10.1007/s00441-011-1213-7.

Diermeier-Daucher D, Breindl S, Buchholz S, Ortmann O, Brockhoff G: Modular anti-EGFR and Her2 targeting of SK-BR-3 and BT474 breast cancer cell lines in the presence of ErbB-receptor specific growth factors. Cytometry A. 2011 Sep;79(9):684-93. doi: 10.1002/cyto.a.211072011

Viale-Bouroncle S, Brockhoff G, Völlner F, Möhle C, Küpper K, Reichert TE, Schmalz G, Morsczeck C: Soft matrix osteogenic differentiation of human dental follicle cells. Biochem Biophys Res Commun. 2011 Jul 8;410(3):587-92. Epub 2011 Jun 12

Wege AK, Ernst W, Vollmann-Zwerenz A, Männel DN, Ortmann O, Kroemer A, Brockhoff G: Humanized tumor mice - a new model to study and manipulate the immunological response in advanced cancer. Int J Cancer. Int J Cancer. 2011 May 4. doi: 10.1002/ijc.26159. [Epub ahead of print]

Plander M, Seegers S, Orsó E, Schmitz G, Hofstädter F, Ugocsai P, Brockhoff G: Chronic lymphocytic leukemia cells induce anti-apoptotic effects of bone marrow stroma. Ann Hematol. 2011 Dec;90(12):1381-90. Epub 2011 Apr 5.

Brockhoff G, Bock M, Gantner S, Hafner C: No evidence for ErbB4-gene amplification in malignant melanoma. Acta Derm Venereol 2011 Jun;91(4):488-90.

Schwarz S, Stiegler C, Müller M, Ettl T, Brockhoff G, Zenk J, Agaimy A: Salivary Gland Mucoepidermoid Carcinoma is a Clinically, Morphologically and Genetically Heterogeneous Entity. A Clinicopathologic Study of 40 Cases with Emphasis on Grading, Histological Variants and Presence of the t(11;19) Translocation. Histopathology. 2011 Mar;58(4):557-70. doi: 10.1111/j.1365-2559.2011.03777.x. Epub 2011 Mar 3.

Felthaus O, Ettl T, Gosau M, Driemel O, Brockhoff G, Reck A, Zeitler K, Hautmann M, Reichert TE, Schmalz G, Morsczeck C: Cancer stem cell-like cells from a single cell of oral squamous carcinoma cell lines. Biochem Biophys Res Commun. 2011 Apr 1;407(1):28-33.


Berezowska S, Diermeier-Daucher S, Brockhoff G, Busch R, Duyster J, Grosu AL, Schlegel J: Effect of additional inhibition of human epidermal growth factor receptor 2 with the bispecific tyrosine kinase inhibitor AEE788 on the resistance to specific EGFR inhibition in glioma cells. Int J Mol Med. 2010 Nov;26(5):713-2

Brunner K, Fischer CA, Driemel O, Hartmann A, Brockhoff G, Schwarz S. EGFR (HER) family protein expression and cytogenetics in 219 squamous cell carcinomas of the upper respiratory tract: ERBB2 overexpression independent prediction of poor prognosis. Anal Quant Cytol Histol. 2010 Apr;32(2):78-89.

Rasper M, Brockhoff G, Piontek G, Teufel J, Ringel F, Zimmer C, Schäfer A, Schlegel J: Aldehyde Dehydrogenase 1 Positive Glioblastoma Cells Show Brain Tumor Stem Cell Capacity. Neuro Oncol. 2010 Oct;12(10):1024-33.

Wohlschlaeger J, Levkau B, Brockhoff G, Schmitz KJ, von Winterfeld M, Takeda A, Takeda N, Stypmann J, Vahlhaus C, Schmid C, Pomjanski N, Böcking A, Baba HA: Hemodynamic support by left ventricular assist devices reduces cardiomyocyte DNA content in the failing human heart. Circulation. 2010 Mar 2;121(8):989-96.

Vollmann-Zwerenz A, Diermeier-Daucher S, Wege AK, Sassen A, Schmidt-Brücken E, Hofstaedter F, Ortmann O, Nauwelaers F, Brockhoff G: Multichromatic phenotyping of ErbB receptor coexpression in breast tumor tissue samples using flow cytometry – Possibilities and limitations. Cytometry A. 2010 Feb 11;77A(4):387-398.

Pohl F, Grosse J, Grimm D, Brockhoff G, Schmidt-Bruecken E, Westphal K, Moosbauer J, Koelbl O, Infanger M, Eilles C, Schoenberger J. Changes of apoptosis, p53 and bcl-2 by irradiation in poorly differentiated thyroid carcinoma cell lines – a prognostic marker for prospect of therapeutic success? Thyroid. 2010 Feb;20(2):159-66


Wagner K, Couillard-Despres S, Lehner B, Brockhoff G, Rivera FJ, Blume A, Neumann I, Aigner L. Prolactin induces MAPK signaling in neural progenitors without alleviating glucocorticoid-induced inhibition of in vitro neurogenesis. Cell Physiol Biochem. 2009;24(5-6):397-406.

Buchholz S, Seitz S, Schally AV, Engel JB, Rick FG, Szalontay L, Hohla F, Krishan A, Papadia A, Gaiser T, Brockhoff G, Ortmann O, Diedrich K, Köster F. Triple-negative breast cancers express receptors for luteinizing hormone-releasing hormone (LHRH) and respond to LHRH antagonist Cetrorelix with growth inhibition. Int J Oncol. 2009 Oct;35(4):789-96.

Plander M, Seegers S, Ugocsai P, Diermeier-Daucher S, Iványi J, Schmitz G, Hofstädter F, Schwarz S, Orsó E, Knüchel R, Brockhoff G: Different Proliferative and Survival Capacity of CLL-Cells in a Newly Established in vitro Model for Pseudofollicles. Leukemia. Nov;23(11):2118-28, 2009

Sassen A, Diermeier-Daucher D, Sieben M, Ortmann O, Hofstaedter F, Schwarz S, Brockhoff G: Presence of HER4 associates with increased sensitivity to Herceptin in patients with metastatic breast cancer. Breast Cancer Res. 2009;11(4):R50. Epub 2009 Jul 22.

Diermeier-Daucher S, Clarke ST, Hill D, Vollmann-Zwerenz A, Bradford JA, Brockhoff G: Cell type specific applicability of 5-ethynyl-2’-deoxyuridine (EdU) for dynamic proliferation assessment in flow cytometry. Cytometry A. 2009 Jun;75(6):535-46.


Sassen A, Rochon J, Wild PJ, Hartmann A, Hofstaedter F, Schwarz S, Brockhoff G:
Cytogenetic analysis of HER1/EGFR, HER2, HER3, and HER4 in 278 breast cancer patients. Breast Cancer Res. 2008 Jan 8;10(1):R2

Diermeier-Daucher S, Hasmann M, Brockhoff G: Flow cytometric FRET analysis of erbB receptor interaction on a cell-by-cell basis. Ann N Y Acad Sci. 2008;1130:280-6.

Schwarz S, Bier J, Driemel O, Reichert TE, Hauke S, Hartmann A, Brockhoff G: Losses of FHIT and p16 as shown by fluorescence in situ hybridization (FISH) are early events in tumorigenesis of oral squamous cell carcinoma and already occur in simple keratosis. Cytometry A. 2008 Apr;73(4):305-11

Schwarz S, Rechenmacher M, Filbeck T, Knuechel R, Hartmann A, Brockhoff G: Value of multicolour Fluorescence-in-situ-hybridization (UroVysionTM) in the differential diagnosis of flat urothelial lesions. J Clin Pathol. 2008 Mar;61(3):272-7

Weiss TS, Lichtenauer M, Kirchner S, Stock P, Aurich H, Christ B, Brockhoff G, Kunz-Schughart LA, Jauch KW, Schlitt HJ, Thasler WE. Hepatic progenitor cells from adult human livers for cell transplantation. Gut. 2008 Aug;57(8):1129-38.

Gottfried E, Kunz-Schughart L, Rehli M, Kastenberger M, Brockhoff G, Andreesen R, Kreutz M: Expression of CD68 in non-myeloid cell types. Scand J Immunol. May;67(5):453-63, 2008


Denzinger S, Stoehr R, Schwarz S, Eichenseher N, Brockhoff G, Obermann EC, Knuechel R, Blaszyk H, Hartmann A, Wild PJ.: Low level STK15 amplification in histologically benign urothelium of patients with bladder cancer adversely predicts patient outcome following cystectomy. Int J Oncol. 2007 Oct;31(4):793-802.

Brockhoff G, Heckel B, Schmidt-Brücken E, Hofstaedter F, Vollmann A, Diermeier S: Differential impact of Cetuximab, Pertuzumab and Trastuzumab on BT474 and SK-BR-3 breast cancer cell proliferation. Cell Prolif. 2007 Aug;40(4):488-507

Schweikl H, Hartmann A, Hiller KA, Spagnuolo G, Bolay C, Brockhoff G, Schmalz G: Inhibition of TEGDMA and HEMA-induced genotoxicity and cell cycle arrest by N-acetylcysteine. Dent Mater. 2007 Jun;23(6):688-95


Schaefer KL, Brachwitz K, Braun Y, Diallo R, Wai DH, Brockhoff G, Vollmann A, Zahn S, Schneider DT, Kuhnen C, Gabbert HE, Poremba C: Constitutive activation of neuregulin / ERBB3 signaling pathway in clear cell sarcoma of soft tissue. Neoplasia. 2006 Jul;8(7):613-22

Vollmann A, Vornlocher HP, Stempfl T, Brockhoff G, Apfel R, Bogdahn U: Glioma cells escape specific siRNA mediated siliencing of EGFR in vitro. Int J Oncol. Jun;28(6):1531-42, 2006


Lottner C, Schwarz S, Diermeier S, Knuechel R, Hofstaedter F, Brockhoff G: Authors' reply. J Pathol. 2005 May 26

Diermeier S, Horvath G, Knuechel R, Hofstaedter F, Szollosi J, Brockhoff G: EGFR coexpression modulates susceptibility to Herceptin in HER2/neu overexpressing breast cancer cells. Exp Cell Res. 2005 Apr 1;304(2):604-19.

Lottner C, Schwarz S, Hartmann A, Diermeier S, Knuechel R, Hofstaedter F, Brockhoff G: Simultaneous detection of HER2/neu gene amplification and protein overexpression in paraffin-embedded breast cancer. J Pathol. 2005 Feb 24

Staiger H, Brockhoff G: The role of PDGF-dependent postconfluent mitoses in differentiating 3T3-L1 preadipocytes. Diabetes und Stoffwechsel 2005 14:181-187

Schweikl H, Altmannsberger I, Hanser N, Hiller KA, Bolay C, Brockhoff G, Spagnuolo G, Galler K, Schmalz G: The effect of Triethylene Glycol Dimethacrylate on the cell cycle of mammalian cells. Biomaterials 2005 Jul;26(19):4111-4118


Schwarz S, Rechenmacher M, Lottner C, Brockhoff G, Hartmann A, Langer S, Knuechel R: FISH analysis in the differential diagnosis of flat urothelial lesions using tissue microarrays. Verh Dtsch Ges Pat. 2004 88:184-193

Diermeier S, Schmidt-Brücken E, Kubbies M, Kunz-Schughart LA, Brockhoff G: Continuous Bromodeoxyuridine (BrdU) exposition differentially affects cell cycle progression of human breast and bladder cancer cell lines. Cell Prolif. 2004 Apr;37(2):195-206.


Kunz-Schughart LA, Weber A, Rehli M, Gottfried E, Brockhoff G, Krause SW, Andreesen R Kreutz M: The ‘classical’ macrophage marker CD68 is strongly expressed in primary human fibroblasts. Verh Dtsch Ges Pat. 2003 87:215-223.

Ewing P, Wilke A, Brockhoff G, Andreesen R, Eissner G, Holler E, Gerbitz A: Isolation and transplantation of allogeneic pulmonary endothelium derived from GFP transgenic mice. J Immunol Methods. 2003 283:307-315.

Brockhoff G, Plander M, Barlage S, Schwarz S, Rothe G, Knuechel R: Optimization of three and four color multiparameter DNA analysis in lymphoma specimens. Cytometry. 2003 Jul;54A(1):66-74.

Silzle T, Kreutz M, Dobler MA, Brockhoff G, Knuechel R, Kunz-Schughart LA. Tumor-associated fibroblasts recruit blood monocytes into tumor tissue. Eur J Immunol. 2003 May;33(5):1311-20.

1994 - 2002

Bergmeier W, Schulte V, Brockhoff G, Bier U, Zirngibl H, Nieswandt B. Flow cytometric detection of activated mouse integrin alphaIIbbeta3 with a novel monoclonal antibody. Cytometry. 2002 Jun 1;48(2):80-6.

Becke FM, Hehlgans T, Brockhoff G, Maennel DN. Development of allergic contact dermatitis requires activation of both tumor necrosis factor-receptors. Eur Cytokine Netw. 2001 Mar;12(1):45-50.

Brockhoff G, Heiss P, Schlegel J, Hofstaedter F, Knuechel R. Epidermal growth factor receptor, c-erbB2 and c-erbB3 receptor interaction, and related cell cycle kinetics of SK-BR-3 and BT474 breast carcinoma cells. Cytometry. 2001 Aug 1;44(4):338-48.

Langstein J, Becke FM, Sollner L, Krause G, Brockhoff G, Kreutz M, Andreesen R, Schwarz H. Comparative analysis of CD137 and LPS effects on monocyte activation, survival, and proliferation. Biochem Biophys Res Commun. 2000 Jun 24;273(1):117-22.

Brockhoff G, Fleischmann S, Meier A, Wachs FP, Hofstaedter F, Knuechel R. Use of a mechanical dissociation device to improve standardization of flow cytometric cytokeratin DNA measurements of colon carcinomas. Cytometry. 1999 Aug 15;38(4):184-91.

Ruschoff J, Wallinger S, Dietmaier W, Bocker T, Brockhoff G, Hofstaedter F, Fishel R. Aspirin suppresses the mutator phenotype associated with hereditary nonpolyposis colorectal cancer by genetic selection. Proc Natl Acad Sci U S A. 1998 Sep 15;95(19):11301-6.

Brockhoff G, Wieland W, Woelfl G, Hofstaedter F, Knuechel R. Evaluation of flow-cytometric three-parameter analysis for EGFR quantification and DNA assessment in human bladder carcinomas. Virchows Arch. 1998 Jan;432(1):77-84

Brockhoff G, Endl E, Minuth W, Hofstaedter F, Knuechel R. Options of flow cytometric three-colour DNA measurements to quantitate EGFR in subpopulations of human bladder cancer. Anal Cell Pathol. 1996 Jun;11(1):55-70.

Brockhoff G, Hofstaedter F, Knuechel R. Flow cytometric detection and quantitation of the epidermal growth factor receptor in comparison to Scatchard analysis in human bladder carcinoma cell lines. Cytometry. 1994 Sep 1;17(1):75-83.

nach oben


Heller A, Brockhoff G, Göpferich A: Targeting drugs to mitochondria. Eur J Pharm Biopharm. 2012 Sep;82(1):1-18.Jun 8

Brockhoff G, Bock M, Mund A, Hauke S: mRNA HER2 FISH: A potential auxiliary cytogenetic tool for HER2 diagnosis in breast cancer. G.I.T. Imaging and Microscopy. 1/2010 12:32-35. ISSN 1439

Brockhoff G, Bock M, Mund A, Hauke S: mRNA HER2 FISH: A potential auxiliary cytogenetic tool for HER2 diagnosis in breast cancer. Europe BIOforum. Trends and Techniques in Life Science Research. G.I.T. 2010

Brockhoff G, Rothe G: DGfZ-ESCCA joint abstracts from The 18th Annual Meeting of The German Society of Cytometry (DGfZ) and The 8th Euroconference of Clinical Cell Analysis by The European Society for Clinical Cell Analysis (ESCCA). Cytometry B Clin Cytom. 2008 Oct 27;74B(6):377.

Sassen A, Brockhoff G: M-FISH and QuantiFISH: Automated quantification of multicolor Fluorescence-in-situ-Hybridization in primary tissues. G.I.T. Imaging and Microscopy. 02/2008:46-49, 2008

Sassen A, Brockhoff G: M-FISH and QuantiFISH: Automated quantification of multicolor Fluorescence-in-situ-Hybridization in primary tissues. Europe BIOforum. Trends and Techniques in Life Science Research. G.I.T. 05/2008:42-44, 2008

Brockhoff G: 17th annual conference of the German Society of Cytometry – Welcome note. Cytometry Part A 71A: 739-741, 2007

Tarnok A, Brockhoff G: A Lifelong Dedication to Cytometry - A Tribute to Guenter Valet. 21 Aug, 2007 Published Online: Cytometry Part A.

Brockhoff G: Cytomics and Receptor Interaction. Verh Dtsch Ges Path 2006 90:31-38

Tarnok A, Bocsi J, Brockhoff G. Cytomics - importance of multimodal analysis of cell function and proliferation in oncology. Cell Prolif. 2006 39(6):495-505

Tarnok A, Brockhoff G. Cytomics emerging from cytometry. Cell Prolif. 2006 Oct 39(5):335-8.

Brockhoff G, Mueller S, Sarraf C, Tarnok A: Predictive Medicine and Clinical Cytomics Research - Résumé of the 15th Annual Meeting of the German Society for Cytometry (Deutsche Gesellschaft fuer Zytometrie, DGfZ), Cell Prolif, 2006 Apr;39(2):75-8

Brockhoff G, Knuechel R: Flow cytometric DNA-analysis in oncology: From single to multiparametric measurements. J Lab Med. 2003 Jun 27:5-6:167-174.

Nap M, Brockhoff G, Brandt B, Knuechel R, Leers MP, Schmidt H, De Angelis G, Eltze E, Semjonow A. Flow cytometric DNA and phenotype analysis in pathology. A meeting report of a symposium at the annual conference of the German Society of Pathology, Kiel, Germany, 6-9 June 2000. Virchows Arch. 2001 May;438(5):425-32.)

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Diermeier-Daucher S, Brockhoff G: Dynamic proliferations assessement in flow cytometry. Current Protocols in Cell Biology (CPCB), 2010

Brockhoff G: Flow Cytometric DNA und Proliferation Analysis. In: „Cellular Diagnostics – Principles, Methods and Clinical Applications in Flow Cytometry“. pp 390 – 425. ISBN-13: 978-3-8055-8555-2. Eds.: Sack, Rothe, Karger Publishing, 2009

Diermeier-Daucher S, Brockhoff G: Flow Cytometric FRET Analysis of (erbB-) Receptor-Tyrosine-Kinase Interaction. Curr Protoc Cytom (Ed.: J. Paul Robinson). 2008 Jul;Chapter 12:Unit12.14. ISBN: 1934-9297

Brockhoff G: DNA und Proliferationsmessungen in der Durchflusszytometrie. In: „Zelluläre Diagnostik – Grundlagen, Methoden und klinische Anwendungen der Durchflußzytometrie“. pp 604 – 646. Eds.: Sack, Rothe, Karger Verlag, Okt 2006 ISBN 3-8055-7928-4

Knuechel R, Brockhoff G, Endl E, Steinbach P: Durchflußzytometrie: Stand und Perspektiven in der onkologischen Diagnostik. In: Aktuelle Aspekte der Tumorimmunologie in der Gynäkologie, Kreienberg R, Grill HJ, Möbus V, Koldovsky U (Hrsg.), 1995 ISBN 3-88603-533-6

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Kontaktieren Sie uns

Prof. Dr. rer. nat. Gero Brockhoff

Klinik für Frauenheilkunde ud Geburtshilfe:
Universität Regensburg c/o UKR
Franz-Josef-Strauß-Allee 11
93053 Regensburg
Tel: 0941/944-8910

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