Klinik für Urologie - Lehrstuhl der Universität Regensburg

Publikationen

Publikationen zur experimentellen Urologie aus unserer Klinik seit der Gründung 2003

Epithelial-mesenchymal transformation markers E-cadherin and survivin predict progression of stage pTa urothelial bladder carcinoma. Breyer J, Gierth M, Shalekenov S, Aziz A, Schäfer J, Burger M, Denzinger S, Hofstädter F, Giedl C, Otto W. World J Urol. 2015 Sep 22.

A switch from epithelial to mesenchymal properties correlates with lymphovascular invasion in squamous cell carcinoma of the penis. May M, Brookman-May S, Burger M, Koch S, Otto W, Bründl J, Albrecht K, Denzinger S. Pathol Res Pract. 2015 Sep;211(9):641-5

Loss of AQP3 protein expression is associated with worse progression-free and cancer-specific survival in patients with muscle-invasive bladder cancer. Rubenwolf P, Thomas C, Denzinger S, Hartmann A, Burger M, Georgopoulos NT, Otto W. World J Urol. 2015 May 5.

Anatomical Study of Pelvic Nerves in Relation to Seminal Vesicles, Prostate and Urethral Sphincter: Immunohistochemical Staining, Computerized Planimetry and 3-Dimensional Reconstruction. Ganzer R, Stolzenburg JU, Neuhaus J, Weber F, Fuchshofer R, Burger M, Bründl J. J Urol. 2015 Apr;193(4):1205-12

Computerized quantification and planimetry of prostatic capsular nerves in relation to adjacent prostate cancer foci.
 Bründl J, Schneider S, Weber F, Zeman F, Wieland WF, Ganzer R. Eur Urol. 2014;65(4): 802-8

Epigenetic inactivation of ITIH5 promotes bladder cancer progression and predicts early relapse of pT1 high-grade urothelial tumours.
Rose M, Gaisa NT, Antony P, Fiedler D, Heidenreich A, Otto W, Denzinger S, Bertz S, Hartmann A, Karl A, Knüchel R, Dahl E. Carcinogenesis. 2014;35(3): 727-36

Combination of CK20 and Ki-67 immunostaining analysis predicts recurrence, progression, and cancer-specific survival in pT1 urothelial bladder cancer.
Bertz S, Otto W, Denzinger S, Wieland WF, Burger M, Stöhr R, Link S, Hofstädter F, Hartmann A. Eur Urol. 2014;65(1): 218-26

Diagnostic and prognostic impact of peritumoral stromal remodeling in patients with surgically treated invasive penile squamous cell cancer.
Gunia S, Jain A, Albrecht K, Koch S, Otto W, Denzinger S, Götz S, Niessl N, Burger M, May M. Hum Pathol. 2014;45(6): 1169-76

Outcome of patients with pathological tumor stage T3 urothelial carcinoma of the bladder following radical cystectomy in a single-center series with 116 patients.
Breyer J, Denzinger S, Otto W, Bründl J, Gierth M, Fritsche HM, Rößler W, Wieland WF, Giedl C, Hofstädter F, Rubenwolf P, Burger M, Aziz A. Urol Int. 2014;93(3): 311-9

Is the striated urethral sphincter at risk by standard suture ligation of the dorsal vascular complex in radical prostatectomy? An anatomic study.
Ganzer R, Stolzenburg JU, Neuhaus J, Weber F, Burger M, Bründl J. Urology. 2014;84(6): 1453-60

Expression of aquaporin water channels in human urothelial carcinoma: correlation of AQP3 expression with tumour grade and stage.
Rubenwolf PC, Otto W, Denzinger S, Hofstädter F, Wieland W, Georgopoulos NT. World J Urol. 2014;32(4): 991-7

Ki-67, mini-chromosome maintenance 2 protein (MCM2) and geminin have no independent prognostic relevance for cancer-specific survival in surgically treated squamous cell carcinoma of the penis. May M, Burger M, Otto W, Hakenberg OW, Wieland WF, May D, Hofstädter F, Götz S, Niessl N, Fritsche HM, Birnkammer K, Gilfrich C, Peter J, Jain A, Koch S, Lebentrau S, Riedmiller H, Rössler W, Denzinger S, Brookman-May S, Gunia S. BJU Int. 2013;112(4): E383-90

Introduction and first clinical application of a simplified immunohistochemical validation system confirms prognostic impact of KI-67 and CK20 for stage T1 urothelial bladder carcinoma: single-center analysis of eight biomarkers in a series of three hundred six patients.
Otto W, Denzinger S, Fritsche HM, Burger M, Rößler W, Bertz S, May M, Hartmann A, Hofstädter F, Wieland WF, Eder F. Clin Genitourin Cancer. 2013; Dec;11(4):537-44

Persistent histological changes in the exstrophic bladder after primary closure-a cause for concern? Rubenwolf PC, Eder F, Ebert AK, Hofstaedter F, Woodhouse CR, Roesch WH. J Urol. 2013;189(2): 671-7 


Anatomic study of periprostatic nerve distribution: immunohistochemical differentiation of parasympathetic and sympathetic nerve fibres. Ganzer R., Stolzenburg JU, Wieland F
WF, Bründl J. Eur Urol. 2012;62(6): 1150-6

Loss of aquaporin 3 protein expression constitutes an independent prognostic factor for progression-free survival: an immunohistochemical study on stage pT1 urothelial bladder cancer.
Otto W, Rubenwolf PC, Burger M, Fritsche HM, Rößler W, May M, Hartmann A, Hofstädter F, Wieland WF, Denzinger S. BMC Cancer. 2012;12(1): 459

Aquaporin 3 protein expression in transitional cell carcinoma: a potential marker with regard to tumour progression and prognosis?
Rubenwolf PC, Denzinger S, Otto W. Eur Urol. 2012;61(3): 627-8

Immunohistochemical marker panel differentiates between the three most common subtypes of renal cell carcinoma independent from histomorphologic criteria.
Walter B, Hartmann A, Hofstädter F, Junker K, Moch H, Bertz S, Denzinger S, Otto W, Gajda M, Stoehr CG. Virchows Arch. 2012;460(3): 343-52

First analysis of immune cell infiltration in stage pT1 urothelial bladder carcinoma: CD3 positivity as a prognostic marker for cancer-specific survival.
Otto W, Denzinger S, Wieland WF, Hartmann A. World J Urol. 2012;30(6): 875-7

Substaging by estimating the size of invasive tumour can improve risk stratification in pT1 urothelial bladder cancer-evaluation of a large hospital-based single-centre series.
Bertz S, Otto W, Wieland WF, Stoehr R, Hofstaedter F, Denzinger S, Hartmann A.
Histopathology. 2011 Oct;59(4):722-32

Serine threonine kinase 15 amplification in normal urothelium of cystectomy specimens is no prognostic factor in urothelial carcinoma of the bladder.
Otto W, Fritsche HM, Wild PJ, Wieland WF, Hartmann A, Burger M, Hofstädter F, Denzinger S.
Pathol Res Pract. 2011 Mar 15;207(3):161-3

The WHO classification of 1973 is more suitable than the WHO classification of 2004 for predicting survival in pT1 urothelial bladder cancer.
Otto W, Denzinger S, Fritsche HM, Burger M, Wieland WF, Hofstädter F, Hartmann A, Bertz S.
BJU Int. 2011 Feb;107(3):404-8

DNA adducts of ortho-toluidine in human bladder.
Böhm F, Schmid D, Denzinger S, Wieland WF, Richter E.
Biomarkers. 2011 Mar;16(2):120-8

Can vaccination or tyrosine kinase inhibitor therapy play a role in the adjuvant treatment of renal cell carcinoma?
Brookman-May S, May M, Gilfrich C, Wieland WF, Burger M.
Expert Rev Anticancer Ther. 2010;10(6): 813-23

Multicolor FISH (UroVysion) facilitates follow-up of patients with high-grade urothelial carcinoma of the bladder.
Fritsche HM, Burger M, Dietmaier W, Denzinger S, Bach E, Otto W, Doblinger M, Schwarz S, Buchner H, Hartmann A.
Am J Clin Pathol. 2010;134(4): 597-603

Ongoing outbreak of mumps affecting adolescents and young adults inBavaria,Germany, August to October 2010.
Otto W, Mankertz A, Santibanez S, Saygili H, Wenzel J, Jilg W, Wieland W, Borgmann S.
Euro Surveill. 2010;15(50)

The application of artificial intelligence to microarray data: identification of a novel gene signature to identify bladder cancer progression.
Catto JW, Abbod MF, Wild PJ, Linkens DA, Pilarsky C, Rehman I, Rosario DJ, Denzinger S, Burger M, Stoehr R, Knuechel R, Hartmann A, Hamdy FC.
Eur Urol. 2010;57(3): 398-406

Mutational activation of FGFR3 is not involved in the development of prostate cancer.
Koufou S, Lunz JC, Borchardt A, Keck B, Kneitz B, Gaisa NT, Hafner C, Giedl C, Rau TT, Rogler A, Wieland WF, Hartmann A, Stoehr R.
Pathobiology. 2010;77(5): 249-52

Prognostic value of histopathological tumour growth patterns at the invasion front of T1G3 urothelial carcinoma of the bladder.
Denzinger S, Burger M, Fritsche HM, Bertz S, Hofstädter F, Wieland WF, Hartmann A, Otto W.
Scand J Urol Nephrol. 2009;43(4):282-7

Nerve quantification and computerized planimetry to evaluate periprostatic nerve distribution-does size matter?
Ganzer R, Blana A, Stolzenburg JU, Rabenalt R, Fritsche HM, Wieland WF, Denzinger S.
Urology. 2009 Aug;74(2):398-403
Anatomical description of the periprostatic nerves in the male rhesus monkey (Macaca mulatta).
Ganzer R, Neuhaus J, Gratzke C, Blana A, Wieland WF, Stolzenburg JU.
World J Urol. 2011 Jun;29(3):375-80

No mutations of FGFR3 in normal urothelium in the vicinity of urothelial carcinoma of the bladder harbouring activating FGFR3 mutations in patients with bladder cancer.
Otto W, Denzinger S, Bertz S, Gaumann A, Wild PJ, Hartmann A, Stoehr R.
Int J Cancer. 2009 Nov 1;125(9):2205-8

Mdm2-SNP309 polymorphism in prostate cancer: no evidence for association with increased risk or histopathological tumour characteristics. Stoehr R, Hitzenbichler F, Kneitz B, Hammerschmied CG, Burger M, Tannapfel A, Hartmann A.
Br J Cancer. 2008 Jul 8;99(1):78-82

Topographical anatomy of periprostatic and capsular nerves: quantification and computerised planimetry.
 Ganzer R, Blana A, Gaumann A, Stolzenburg JU, Rabenalt R, Bach T, Wieland WF, Denzinger S. Eur Urol. 2008 Aug;54(2):353-61

Pax-5 protein expression in bladder cancer: a preliminary study that shows no correlation to grade, stage or clinical outcome.
 Denzinger S, Burger M, Hammerschmied CG, Wieland WF, Hartmann A, Obermann EC, Stoehr R.
Pathology. 2008 Aug;40(5):465-9

Prediction of progression of non-muscle-invasive bladder cancer by WHO 1973 and 2004 grading and by FGFR3 mutation status: a prospective study.
Burger M, van der Aa MN, van Oers JM, Brinkmann A, van der Kwast TH, Steyerberg EC, Stoehr R, Kirkels WJ, Denzinger S, Wild PJ, Wieland WF, Hofstaedter F, Hartmann A, Zwarthoff EC.
Eur Urol. 2008 Oct;54(4):835-43

Role of the STK15 Phe31Ile polymorphism in renal cell carcinoma.
Hammerschmied CG, Stoehr R, Walter B, Wieland WF, Hartmann A, Blaszyk H, Denzinger S.
Oncol Rep. 2007 Jan;17(1):3-7

Mcm2 predicts recurrence hazard in stage Ta/T1 bladder cancer more accurately than CK20, Ki67 and histological grade.
Burger M, Denzinger S, Hartmann A, Wieland WF, Stoehr R, Obermann EC.
Br J Cancer. 2007 Jun 4;96(11):1711-5

FGFR3 mutations and a normal CK20 staining pattern define low-grade noninvasive urothelial bladder tumours.
 van Oers JM, Wild PJ, Burger M, Denzinger S, Stoehr R, Rosskopf E, Hofstaedter F, Steyerberg EW, Klinkhammer-Schalke M, Zwarthoff EC, van der Kwast TH, Hartmann A.
Eur Urol. 2007 Sep;52(3):760-8

Low level STK15 amplification in histologically benign urothelium of patients with bladder cancer adversely predicts patient outcome following cystectomy.
 Denzinger S, Stoehr R, Schwarz S, Eichenseher N, Brockhoff G, Obermann EC, Knuechel R, Blaszyk H, Hartmann A, Wild PJ.
Int J Oncol. 2007 Oct;31(4):793-802

Improved clonality analysis of multifocal bladder tumors by combination of histopathologic organ mapping, loss of heterozygosity, fluorescence in situ hybridization, and p53 analyses.
 Denzinger S, Mohren K, Knuechel R, Wild PJ, Burger M, Wieland WF, Hartmann A, Stoehr R.
Hum Pathol. 2006 Feb;37(2):143-51

Chromosome 9 deletions are more frequent than FGFR3 mutations in flat urothelial hyperplasias of the bladder. van Oers JM, Adam C, Denzinger S, Stoehr R, Bertz S, Zaak D, Stief C, Hofstaedter F, Zwarthoff EC, van der Kwast TH, Knuechel R, Hartmann A.

Int J Cancer. 2006 Sep 1;119(5):1212-5

Elevated microsatellite alterations at selected tetranucleotides (EMAST) and mismatch repair gene expression in prostate cancer.
Burger M, Denzinger S, Hammerschmied CG, Tannapfel A, Obermann EC, Wieland WF, Hartmann A, Stoehr R.
J Mol Med. 2006 Oct;84(10):833-41

Mitogen-activated protein kinase signaling is activated in prostate tumors but not mediated by B-RAF mutations. Burger M, Denzinger S, Hammerschmied C, Tannapfel A, Maderstorfer A, Wieland WF, Hartmann A, Stoehr R. Eur Urol. 2006 Nov;50(5):1102-9; discussion 1109-10

Deletions of chromosomes 9 and 8p in histologically normal urothelium of patients with bladder cancer.
 Stoehr R, Zietz S, Burger M, Filbeck T, Denzinger S, Obermann EC, Hammerschmied C, Wieland WF, Knuechel R, Hartmann A.
Eur Urol. 2005 Jan;47(1):58-63

Improved clonality analysis of multifocal bladder tumors by combination of histopathologic organ mapping, loss of heterozygosity, fluorescence in situ hybridization, and p53 analyses. Denzinger S, Mohren K, Knuechel R, Wild PJ, Burger M, Wieland WF, Hartmann A, Stoehr R. Hum Pathol. 2006 Feb;37(2):143-51

Fluorescence in situ hybridization detects frequent chromosome 9 deletions and aneuploidy in histologically normal urothelium of bladder cancer patients. Obermann EC, Meyer S, Hellge D, Zaak D, Filbeck T, Stoehr R, Hofstaedter F, Hartmann A, Knuechel R. Oncol Rep. 2004 Apr;11(4):745-51

No evidence for mutation of B-RAF in urothelial carcinomas of the bladder and upper urinary tract. Stoehr R, Brinkmann A, Filbeck T, Gamper C, Wild P, Blaszyk H, Hofstaedter F, Knuechel R, Hartmann A. Oncol Rep. 2004 Jan;11(1):137-41

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